LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor
نویسندگان
چکیده
منابع مشابه
LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor
Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the plasma membrane. However, this pathogenic mode of processing AβPP may occur in competition with lysosomal degradation...
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ژورنال
عنوان ژورنال: Pathobiology of Aging & Age-related Diseases
سال: 2015
ISSN: 2001-0001
DOI: 10.3402/pba.v5.25796